Telomere Loop (T-Loop)

Mammalian telomeres have been observed in large looped structures called T-loops. In this configuration, POT1 might bind to a single-stranded portion called the D-loop and perhaps to the 3′ end.

A double strand of D-N-A forming a T-loop. The 3 prime and 5 prime ends are marked. POT-1 is shown binding to the D-loop.