Structure of Human POT1 Protein

The human POT1 protein structure differs from that of yeast in that it reveals two adjacent OB folds. The OB fold of a human POT1 binds to the sequence TTAGGGTTAG. It can equally well bind to two telomeric repeats, GGTTAG GGTTAG.

A blue and red colored irregular shaped mass with two folds each containing a telomeric sequence.