Summary of How RNAi Works

In the cytoplasm, outside the nucleus, d-s-R-N-A processing uses Dicer to cut d-s-R-N-A into s-i-R-N-A, converting A-T-P to A-D-P + P-I. s-i-R-N-A then forms an assembly of R-I-S-C. s-i-R-N-A unzipping converts A-T-P to A-D-P + P-I to produce active R-I-S-C. R-I-S-C then binds to target m-R-N-A. Target m-R-N-A cleavage causes sequence-specific gene silencing.
The complete RNAi process, from the initial cutting of double stranded RNA to the final sequence-specific gene silencing.