2000 and Beyond: Confronting the Microbe Menace

Lecture 3 – Outwitting Bacteria's Wily Ways

by B. Brett Finlay, PhD

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  1.  1.  Start of Lecture 3
  2.  2.  Introduction by HHMI Vice President Dr. Joseph Perpich
  3.  3.  Interview with Dr. Brett Finlay: Joy of scientific study
  4.  4.  Lecture Three objectives
  5.  5.  What is a pathogen?
  6.  6.  E. coli introduction
  7.  7.  Two types of E. coli: EPEC and EHEC (0157:H7)
  8.  8.  E. coli infection via ground beef and vegetables
  9.  9.  What does E. coli actually do?
  10. 10.  What virulence factors does E. coli possess?
  11. 11.  Bundle-forming pilus attaches to host
  12. 12.  Animation: E. coli adheres to host using the pilus
  13. 13.  Demonstration: virulence factor injected into host cell
  14. 14.  Type III secretion system
  15. 15.  E. coli injects its own receptors into the host cell
  16. 16.  Virulence factor modifies cell signaling
  17. 17.  Animation: E. coli injects receptor protein into host and binds to it
  18. 18.  E. coli changes host cell cytoskeleton
  19. 19.  Animation: E. coli causes pedestal formation
  20. 20.  Electron micrograph of pedestal in vivo
  21. 21.  Toxins as virulence factors; Shiga toxin in enterohemorrhagic E. coli
  22. 22.  Evolution of pathogenic E. coli
  23. 23.  Potential therapies to fight bacteria
  24. 24.  Introduction to Salmonella
  25. 25.  Microscopic view of live Salmonella
  26. 26.  Virulence factors of Salmonella
  27. 27.  Demonstration: Jell-O simulation of Salmonella invasion
  28. 28.  Video: Living Salmonella invading a cell
  29. 29.  Animation: Salmonella invading a cell
  30. 30.  Salmonella needs to survive and multiply inside the host cell
  31. 31.  Animation: Salmonella inside the host cell
  32. 32.  Bacterial strategies for intracellular survival
  33. 33.  Introduction to Listeria monocytogenes
  34. 34.  Demonstration: Jell-O simulation of Listeria invasion
  35. 35.  Intracellular lifestyle of Listeria
  36. 36.  Video: Live Listeria moving inside the host cell
  37. 37.  Regulation of virulence factor expression
  38. 38.  The future of infectious bacterial diseases
  39. 39.  Student question: Treatment differences for gram-positive and gram-negative bacteria
  40. 40.  Student question: Why don't we have a cure for the common cold?
  41. 41.  Student question: Lysosome avoidance by Listeria-type invaders
  42. 42.  Student question: Is the actin used by bacteria the same as actin/myosin?
  43. 43.  Student question: How do some pathogens mutate faster than others?
  44. 44.  Student question: Are there harmless bacteria in humans that harm animals?
  45. 45.  Student question: How do bacteria survive host cell death?
  46. 46.  Student question: Jungles as a source for antibiotics
  47. 47.  Closing remarks by HHMI Vice President Dr. Joseph Perpich


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