2000 and Beyond: Confronting the Microbe Menace

Lecture 2 – The Microbes Strike Back

by B. Brett Finlay, PhD

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  1.  1.  Start of Lecture 2
  2.  2.  Introduction by HHMI President Dr. Purnell Choppin
  3.  3.  Introductory interview with Dr. Brett Finlay
  4.  4.  Dr. Finlay describes objectives of this lecture
  5.  5.  Demonstration: Size analogy of bacteria
  6.  6.  How does one study bacteria?
  7.  7.  Bacteria are everywhere
  8.  8.  Role of bacteria in body
  9.  9.  Cheek cell demonstration
  10. 10.  Rate of bacterial reproduction
  11. 11.  Video clip: Bacterial growth
  12. 12.  Mortality rate and productivity loss from infection
  13. 13.  List of the leading deadly bacteria
  14. 14.  Susceptibility to disease
  15. 15.  Disease kills more people than bullets do
  16. 16.  Bacteria cause many diseases
  17. 17.  Ulcers and other diseases caused by bacteria
  18. 18.  How do bacteria spread?
  19. 19.  Demonstration: Air transmission of bacteria
  20. 20.  How do we fight bacteria?
  21. 21.  Antibiotics: Penicillin structure
  22. 22.  Origin of antibiotics
  23. 23.  Antibiotic modes of action
  24. 24.  Culture plate showing antibiotics' effect
  25. 25.  Video clip: Penicillin killing E. coli
  26. 26.  Antibiotics increased life expectancy by eight years
  27. 27.  Bacteria can develop antibiotic resistance
  28. 28.  How does antibiotic resistance develop?
  29. 29.  Superbugs
  30. 30.  Bacteria can share antibiotic resistance
  31. 31.  Animation: Conjugation
  32. 32.  Development cost of antibiotics
  33. 33.  How should we use antibiotics?
  34. 34.  Vaccines: Basic facts
  35. 35.  Should everyone be vaccinated?
  36. 36.  List of available vaccines in 1959, 1982, and 1999
  37. 37.  How do we develop a vaccine?
  38. 38.  Genomics of bacteria
  39. 39.  Bioinformatics and the Human Genome Project
  40. 40.  Who will win—humans or bacteria?
  41. 41.  Student question: Why don't we have an AIDS vaccine?
  42. 42.  Student question: Do disinfectants affect resistance?
  43. 43.  Student question: Can we use viruses to kill bacteria?
  44. 44.  Student question: What bacterial disease causes blindness?
  45. 45.  Student question: How do we deal with biological warfare?
  46. 46.  Student question: How does flesh-eating disease work?
  47. 47.  Student question: How do resistances initially develop?
  48. 48.  Student question: How do we treat different areas of the body?
  49. 49.  Student question: Can we use antibiotics years later?
  50. 50.  Student question: Can we modify antibiotics to overcome resistance?
  51. 51.  Closing remarks by HHMI Vice President Dr. Joseph Perpich


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