2000 and Beyond: Confronting the Microbe Menace

Lecture 1 – Microbe Hunters: Tracking Infectious Agents

by Donald E. Ganem, MD
  1.  1.  Start of Lecture 1
  2.  2.  Introduction by HHMI President Dr. Purnell Choppin
  3.  3.  Introductory interview with Dr. Donald Ganem
  4.  4.  Bubonic plague
  5.  5.  Historical account of bubonic plague
  6.  6.  Advances in biology in the 19th and 20th centuries
  7.  7.  Description of HIV and AIDS
  8.  8.  What are epidemics?
  9.  9.  Classes of microbes
  10. 10.  What are viruses?
  11. 11.  Demonstration: Size analogy of infectious agents
  12. 12.  How does a virus infect a cell?
  13. 13.  Animation: Viral infection
  14. 14.  Why do viruses replicate the way they do?
  15. 15.  How do you know if something is an epidemic?
  16. 16.  How would you know if a microbe caused a disease?
  17. 17.  HIV epidemiology
  18. 18.  Job of an epidemiologist
  19. 19.  Classical methods of finding a disease agent
  20. 20.  Genomic method of finding a disease agent
  21. 21.  What is molecular subtraction?
  22. 22.  HIV in Kaposi's sarcoma: A molecular subtraction example
  23. 23.  Epidemiological evidence that HIV is not the sole cause of Kaposi's sarcoma
  24. 24.  Molecular subtraction shows herpes is involved in Kaposi's sarcoma
  25. 25.  Herpes virus isolated from Kaposi's sarcoma patient
  26. 26.  Herpes virus as the causative agent of Kaposi's sarcoma
  27. 27.  Koch's postulates
  28. 28.  Other methods for determining causality
  29. 29.  Summary of Kaposi's sarcoma
  30. 30.  Herpes virus needs cofactors to cause Kaposi's sarcoma
  31. 31.  Future directions for research in Kaposi's sarcoma
  32. 32.  Student question: Latent infection
  33. 33.  Student question: Evolutionary advantage of latency
  34. 34.  Student question: What activates a latent agent?
  35. 35.  Student question: Herpes virus diversity
  36. 36.  Student question: Cell surface receptors
  37. 37.  Student question: Viral DNA interaction with human DNA
  38. 38.  Student question: Going from fragment to whole viral genome
  39. 39.  Closing remarks by HHMI President Dr. Purnell Choppin


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