The Double Life of RNA
Lecture 4 – Life at the End of the Chromosome: Another RNA Machine
by Thomas R. Cech, Ph.D.
2010 Infectious Diseases
2009 Biodiversity
2008 Neuroscience
2007 HIV/AIDS
2006 Stem Cells
2006 Evolution
2005 Evolution
2004 Obesity
2003 Cancer/Neuroscience
2002 Genomics/Chemical Genetics
2001 Sex Determination
2000 Biological Clocks
1999 Infectious Diseases
1998 Cardiovascular Diseases
1997 Neuroscience
1995 RNA
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Lecture 1 – Catalysis: Chemical and Biochemical
Lecture 2 – RNA as an Enzyme: Discovery, Origins of Life, and Medical Possibilities
Lecture 3 – How to Accelerate a Reaction 100,000,000,000 Times Using Only RNA
Lecture 4 – Life at the End of the Chromosome: Another RNA Machine
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1.
Start of Lecture 4
2.
Introduction by HHMI Vice President Dr. Joseph Perpich
3.
Human chromosomes and their replication
4.
What happens at the end of the chromosomes?
5.
Functions of telomeres
6.
DNA sequences of telomeres in different species
7.
Oxytricha
as a source of telomere proteins
8.
How do the telomere proteins interact with DNA?
9.
The 3D structure of telomere proteins
10.
Replication problems at the ends of the DNA strand
11.
Telomerase solves the end-replication problem
12.
Using PCR to clone telomerase RNA genes
13.
Telomerase RNA is similar across different species
14.
Using antibodies to tag proteins in a cell
15.
Alpha/beta telomere protein location in the nucleus
16.
Using an RNA probe to tag telomerase RNA
17.
Location of telomerase suggests its replication role
18.
Summary
19.
Cech lab personnel and path of scientific training
20.
Q&A: What are telomerases doing in "storage"?
21.
Closing remarks by HHMI President Choppin
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