Viral Outbreak: The Science of Emerging Disease

Lecture 4 – Solving SARS and Other Viral Mysteries

by Joe DeRisi, PhD

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  1.  1.  Start of Lecture 4
  2.  2.  Welcome by HHMI President Dr. Robert Tjian
  3.  3.  Profile of Dr. Joseph DeRisi
  4.  4.  SARS: A global epidemic
  5.  5.  Origin of SARS epidemic
  6.  6.  Case definition of SARS
  7.  7.  SARS spreads worldwide
  8.  8.  Virochip identifies SARS virus
  9.  9.  Sequencing confirms SARS is caused by a new coronavirus
  10. 10.  SARS epidemic stopped in 6 months
  11. 11.  SARS coronavirus originally came from horseshoe bat
  12. 12.  Proventricular dilatation disease (PDD): Mysterious parrot disease
  13. 13.  Virochip indicates bornavirus may cause PDD
  14. 14.  Ultra-deep sequencing reads hundreds of millions of bases at once
  15. 15.  Assembling sequences to get complete viral genome
  16. 16.  Comparing sequences to known bornavirus genomes
  17. 17.  Testing that the candidate bornavirus causes PDD
  18. 18.  Q&A: What challenges did you face in developing the Virochip?
  19. 19.  Q&A: Where did the index patient get SARS originally?
  20. 20.  Q&A: Has treatment been developed for SARS?
  21. 21.  Q&A: What makes SARS so much more transmittable?
  22. 22.  Finding novel viruses in a Nicaraguan cohort
  23. 23.  Bioinformatic filtering of deep-sequencing data to find viral DNA
  24. 24.  Discovery of EV109, a novel enterovirus
  25. 25.  Full-sequence analysis shows EV109 combines 3 viruses
  26. 26.  Comparison of advances in DNA sequencing to advances in telescopes
  27. 27.  Sequencing your personal genome
  28. 28.  Sequencing all the microbes associated with humans
  29. 29.  Q&A: Are there other sequencing technologies?
  30. 30.  Q&A: Are we born colonized by bacteria and viruses?
  31. 31.  Q&A: Can DNA chips be used to identify diverse HIV types?
  32. 32.  Q&A: How does zoonosis occur?
  33. 33.  Closing remarks by HHMI President Dr. Robert Tjian


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