Potent Biology: Stem Cells, Cloning and Regeneration

Lecture 2 – Adult Stem Cells and Regeneration

by Nadia Rosenthal, PhD
  1.  1.  Start of Lecture 2
  2.  2.  Welcome by HHMI Vice President Dr. Peter Bruns
  3.  3.  Dr. Rosenthal in the lab
  4.  4.  Overview of differentiation
  5.  5.  Replenishment and renewal of the body
  6.  6.  Some cells replenish constantly
  7.  7.  Replenishment vs. regeneration
  8.  8.  The myth of Prometheus and liver regeneration
  9.  9.  Is wound healing regeneration?
  10. 10.  Stem cells are rare in adults
  11. 11.  Some animals can regenerate body parts
  12. 12.  Planaria regeneration and stem cells
  13. 13.  Student experiments on planaria regeneration
  14. 14.  Stem cells activated in regenerating planaria
  15. 15.  Demo: The fire-bellied newt
  16. 16.  Animation: Newt limb regeneration
  17. 17.  Muscle cells contributed to skin in regenerating limb
  18. 18.  Can humans regenerate body parts?
  19. 19.  Q&A: Why can't the newt arm grow a new newt?
  20. 20.  Q&A: Could you put newt stem cells into a human?
  21. 21.  Q&A: What happens to muscle in limb lengthening?
  22. 22.  Q&A: Can a newt regenerate its organs?
  23. 23.  Q&A: How many times will the newt limb regenerate?
  24. 24.  Q&A: What triggers cells to form the blastema?
  25. 25.  Problems with mammalian regeneration
  26. 26.  Dedifferentiation of cells during regeneration
  27. 27.  Cancer and dedifferentiation are similar
  28. 28.  Controlled cell proliferation in the newt
  29. 29.  Are regenerative genes lost in higher organisms?
  30. 30.  Identifying the signals that control limb regrowth
  31. 31.  The CD59 protein may guide newt limb regrowth
  32. 32.  Overexpressing CD59 causes malformation
  33. 33.  Demo: Regeneration of deer antlers
  34. 34.  Adult stem cells in bone marrow and muscle
  35. 35.  Muscular dystrophy overwhelms stem cell capacity
  36. 36.  Using bone marrow cells to repair dystrophic muscle
  37. 37.  Growth factor IGF-1: Function and mechanism
  38. 38.  IGF-1 improves bond marrow's ability to regrow muscle cells
  39. 39.  Summary of regeneration schemes
  40. 40.  Q&A: Could stem cells reverse the effects of liver cancer?
  41. 41.  Q&A: Why do we age if we can regenerate cells?
  42. 42.  Q&A: How far up a newt's limb can you cut?
  43. 43.  Q&A: Are skin markings identical on the regrown newt limb?
  44. 44.  Q&A: Can a newt regrow two limbs at once?
  45. 45.  Closing remarks by HHMI Vice President Dr. Peter Bruns


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