Learning from Patients: The Science of Medicine

Lecture 2 – Chaos to Cure: Bringing Basic Research to Patients

by Bert Vogelstein, MD

  1.  1.  Start of Lecture 2
  2.  2.  Introduction by HHMI Vice President Dr. Peter Bruns
  3.  3.  Introductory interview with Dr. Bert Vogelstein
  4.  4.  Three ways of using genetic knowledge to help cancer patients
  5.  5.  Risk assessment and pedigree symbols
  6.  6.  Genetic test for detecting FAP patients
  7.  7.  Ethical issues in sharing genetic-testing information
  8.  8.  Using genetically engineered mice to find treatments for FAP
  9.  9.  Early detection of polyps to help nonfamilial cases
  10. 10.  Video: Today host Katie Couric's colonoscopy
  11. 11.  Video: Polypectomy
  12. 12.  Need for developing noninvasive techniques to detect cancer
  13. 13.  Using stool samples to detect mutations
  14. 14.  Q&A: How do you determine what drugs to give FAP mice?
  15. 15.  Q&A: How do you explain the effects of Sulindac and EKI?
  16. 16.  Q&A: Do different cancers develop in different age groups?
  17. 17.  Q&A: What are the body's defenses against cancer?
  18. 18.  Q&A: Do different populations have resistance to cancer?
  19. 19.  Q&A: Can cancers be detected before they are metastatic?
  20. 20.  Q&A: What parts of the body tend to develop metastatic cancers?
  21. 21.  Current treatments for cancer and direction for future
  22. 22.  Cancer cells have altered chromosomes
  23. 23.  Chromosome translocation generates Philadelphia chromosome
  24. 24.  Animation: Gleevec inhibiting the activity of BCR-ABL protein
  25. 25.  Treating leukemia patients with Gleevec
  26. 26.  Animation: Using a virus to kill cancer cells with defective p53
  27. 27.  Animation: Cancer cells recruit blood vessels to grow
  28. 28.  Animation: VEGF released by tumors recruits blood vessels
  29. 29.  Using antiangiogenesis drugs to treat cancer
  30. 30.  Using engineered anaerobic bacteria to treat cancer
  31. 31.  Q&A: Do bacterial and viral therapies have side effects?
  32. 32.  Q&A: Can you poison cancer cells with excess oxygen?
  33. 33.  Q&A: Which treatment do you prefer?
  34. 34.  Q&A: How do you make the new therapies available to everyone?
  35. 35.  Q&A: How does hormone therapy to treat cancer work?
  36. 36.  Q&A: How do anaerobic bacteria survive after eating dead tissue?
  37. 37.  Q&A: Isn't an adenovirus treatment limited by immunity?
  38. 38.  Q&A: Shouldn't stool or blood testing for cancer be made routine?
  39. 39.  Q&A: How do you treat people with multiple cancers?
  40. 40.  Closing remarks by HHMI Vice President Dr. Peter Bruns

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