Scanning Life's Matrix: Genes, Proteins, and Small Molecules

Lecture 3 – Human Genomics: A New Guide for Medicine

by Eric S. Lander, PhD

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  1.  1.  Start of Lecture 3
  2.  2.  Introduction by HHMI Vice President Dr. Peter Bruns
  3.  3.  Introductory interview with Dr. Eric Lander
  4.  4.  Observing what nature has already perturbed
  5.  5.  How similar are the two copies of your DNA?
  6.  6.  How similar is DNA from two people?
  7.  7.  Human origins and why we have little genetic variation
  8.  8.  Tracing human migrations by looking at genetic variation
  9.  9.  What differences do genetic variations make?
  10. 10.  Single nucleotide polymorphism (SNP) can affect Alzheimer disease
  11. 11.  Other examples of variations affecting diseases
  12. 12.  Some mutations can protect against AIDS
  13. 13.  Cataloging all human variations
  14. 14.  Filling in life's matrix: Genes phenotypes, and SNPs
  15. 15.  Examples of genetic bases of human phenotypic variation
  16. 16.  Can "Olympic gold medalist" be a phenotype with a genetic basis?
  17. 17.  Q&A: Are mutation rates different in different species?
  18. 18.  Q&A: Has the mutation rate increased with a larger human population?
  19. 19.  Q&A: Would alcohol digestion problems affect alcoholism?
  20. 20.  Measuring variations in the levels of all RNA expressions
  21. 21.  Can differences in leukemias be detected by microscopy?
  22. 22.  The discovery of two kinds of leukemia: AML and ALL
  23. 23.  Limitations of conventional methods for diagnosing leukemia
  24. 24.  How to make a DNA microarray
  25. 25.  Using microarrays to detect the activities of all the genes in a tumor
  26. 26.  Using microarrays to differentiate AML and ALL
  27. 27.  Using computers to sort RNA expression data
  28. 28.  Discovering a novel type of leukemia
  29. 29.  Building taxonomies for tumors and other biological functions
  30. 30.  Q&A: How accessible is microarray technology to doctors?
  31. 31.  Q&A: Are some mutations inherently bad and selected against?
  32. 32.  Q&A: Wouldn't DNA variation confound the microarray detector mechanism?
  33. 33.  Q&A: Are DNA microchips reusable?
  34. 34.  Closing remarks by HHMI Vice President Dr. Peter Bruns


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