Scanning Life's Matrix: Genes, Proteins, and Small Molecules

Lecture 1 – Reading Genes and Genomes

by Eric S. Lander, PhD

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  1.  1.  Start of Lecture 1
  2.  2.  Introduction by HHMI President Dr. Thomas Cech
  3.  3.  Introductory interview with Dr. Eric Lander
  4.  4.  Geneticists are interested in human variation
  5.  5.  Roots of genetics in the age of exploration
  6.  6.  Gregor Mendel's original study and its rediscovery in 1900
  7.  7.  Review of genetic advances in the 20th century
  8.  8.  The genome as nature's experimental notes
  9.  9.  Reading DNA helps us understand disease
  10. 10.  Finding disease genes by tracing lineage and chromosome walking
  11. 11.  Genetic basis of cystic fibrosis
  12. 12.  The origin and goal of the Human Genome Project
  13. 13.  Demonstration: The '80s way of sequencing DNA
  14. 14.  Video: Today's way of sequencing DNA
  15. 15.  The human genome sequencing timeline
  16. 16.  Sequencing the mouse genome
  17. 17.  Q&A: Does "junk" DNA cause problems in interpreting the genome?
  18. 18.  Q&A: Are most diseases caused by small changes in DNA?
  19. 19.  Q&A: Do genes involved in the same disease have the same promoter?
  20. 20.  Q&A: Could you talk about gene therapy?
  21. 21.  Q&A: What ethical problems do you run into?
  22. 22.  How big is the human genome?
  23. 23.  Video: New York's Fifth Avenue as the human genome
  24. 24.  Finding genes in the genome
  25. 25.  Distribution of genes in the human genome
  26. 26.  The human genome has surprisingly few genes
  27. 27.  Are vertebrate genes different from other species' genes?
  28. 28.  Many vertebrate genes arose from gene duplication followed by variation
  29. 29.  Human and mouse comparisons: The mouse as a model for humans
  30. 30.  Human and mouse comparisons: Genomic similarities
  31. 31.  Human and mouse comparisons: Finding conserved sequences
  32. 32.  Challenges of today and challenges of the future
  33. 33.  Q&A: What is currently being done to figure out non-coding DNA?
  34. 34.  Q&A: How do you prevent the symptoms of the disease PKU?
  35. 35.  Q&A: How would you identify non-disease traits?
  36. 36.  Q&A: Is it possible to treat genetic diseases with proteins?
  37. 37.  Closing remarks by HHMI President Dr. Thomas Cech

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